Acetyl-L-carnitine and alpha-lipoic acid are each impressive supplements in their own right; however, research is showing that in combining these two supplements, the deterioration associated with aging can be subdued or even reversed.
Healthy mitochondria are vital for healthy aging, and this combo is built to make them last. In normal aging, free radicals accumulate instead of being destroyed by the mitochondria. With the Acetyl-L-carnitine and alpha-lipoic acid combo, alpha-lipoic acid triggers the mitochondria to destroy free radicals and the acetyl-L-carnitine boosts the activity of carnitine acetyltransferase, an enzyme largely responsible for burning fuel in the mitochondria. As Dr. Ames said, "Each chemical solves a different problem - the two together are better than either one alone."(1)
Ames went on to say that the dramatic effects on the rats would be similar to a senior citizen behaving like someone in their fifties. A different study found that even young animals treated with the combo had better intact morphology than untreated young animals.
Researchers began to look more closely at the affects of supplementation on memory function. Both spatial and temporal memory improved, and oxidative damage to the hippocampus of the brain decreased. It has been said that the Acetyl-L-carnitine/alpha-lipoic acid combo may also protect from neurodegeneration or cognitive impairment.
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(1) Robert Sanders, “Dietary supplements make old rats youthful, may help rejuvenate aging humans, according to UC Berkeley study,” Press Release, Feb. 19, 2002.